‘Biomarkers of heterogeneity in type 1 diabetes’ study

HJ Aanstoot, R Varkevisser, D Mul, P Dekker, E Birnie, L Boesten, M Brugts, P van Dijk, N Duijvestijn, S Dutta, C Fransman, R Gonera, K Hoogenberg, A Kooy, E Latres, S Loves, G Nefs, T Sas, C Vollenbrock, M Vosjan-Noeverman, M de Vries-Velraeds, H Veeze, B Wolffenbuttel, M van der Klauw

Cohort profile: The ‘Biomarkers of heterogeneity in type 1 diabetes’ study – a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands. BMJ Open 2024 Jun 19;14(6):e082453.

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Metabolomics and hypoglycemia awareness

Rita Varkevisser, Alexander Cecil, Cornelia Prehn, Dick Mul, Henk-Jan Aanstoot, Andrew Paterson, Bruce Wolffenbuttel, Melanie van der Klauw

Metabolomic associations of impaired awareness of hypoglycaemia in type 1 diabetes. Sci Rep. 2024 Feb 23;14(1):4485.

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C-peptide in long-standing T1D

Charlotte Vollenbrock, Dick Mul, Pim Dekker, Erwin Birnie, Martine de Vries, Lianne Boesten, Joost Groen, Nel Geelhoed-Duijvestijn, Henk-Jan Aanstoot, Bruce Wolffenbuttel

Fasting and meal-stimulated serum C-peptide in long-standing type 1 diabetes mellitus. Diabet Med . 2023 Feb;40(2):e15012.

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Diabetes vaccine Diamyd® (GAD65-alum) improves glycemic control in recently diagnosed T1D

Christoph Nowak, Marcus Lind, Zdenek Sumnik, et al. (including Theo Sas of Diabeter)

Intralymphatic GAD-Alum (Diamyd®) Improves Glycemic Control in Type 1 Diabetes With HLA DR3-DQ2. J Clin Endocrinol Metab. 2022 Aug 18;107(9):2644-2651.

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Glycemic variability and pregnancy

Riëlle Hoek-Hogchem, Sarah Bovenberg, Pim Dekker, Erwin Birnie, Henk Veeze, Hans J. Duvekot, Sander Galjaard, Henk-Jan Aanstoot

Effects of peri-conception and pregnancy glycemic variability on pregnancy and perinatal complications in type 1 diabetes: a pilot study. Exp Clin Endocrinol Diabetes. 2022 Nov;130(11):740-750.

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Availability & reporting of technical specifications of C-peptide assays

Pim Dekker, Martine de Vries, Henk-Jan Aanstoot, Joost Groen

Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance. Pediatr Endocrinol Diabetes Metab 2022; 28 (1): 101–103

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Detection limits of C-peptide assays in diabetes research

Kitty de Leur, Charlotte Vollenbrock, Pim Dekker, Martine de Vries, Erwin Birnie, Dick Mul, Bruce H. R. Wolffenbuttel, Joost Groen, Henk-Jan Aanstoot, Lianne Boesten

How low is really low? Comparison of two C-peptide assays to establish residual C-peptide production in type 1 diabetes. Diabet Med. 2022 May;39(5):e14785.

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C-peptide and impaired awareness of hypoglycemia

Martine J Wellens, Charlotte E Vollenbrock, Pim Dekker, Lianne S M Boesten, Petronella H Geelhoed-Duijvestijn, Martine M C de Vries-Velraeds, Giesje Nefs, Bruce H R Wolffenbuttel , Henk-Jan Aanstoot, Peter R van Dijk

Residual C-peptide secretion and hypoglycemia awareness in people with type 1 diabetes. BMJ Open Diabetes Res Care . 2021 Sep;9(1):e002288.

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Diagnode-2: Results from trial with diabetes vaccine Diamyd® (GAD65-alum) published

Johnny Ludvigsson, Zdenek Sumnik, Terezie Pelikanova, et al. (including Theo Sas of Diabeter)

Intralymphatic Glutamic Acid Decarboxylase With Vitamin D Supplementation in Recent-Onset Type 1 Diabetes: A Double-Blind, Randomized, Placebo-Controlled Phase IIb Trial. Diabetes Care . 2021 Jul;44(7):1604-1612.

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Optimizing screening of lipids in children and adolescents with type 1 diabetes

Heyden JCV, Birnie E, Bovenberg SA, Dekker P, Veeze HJ, Mul D, Aanstoot HJ.

Losing Track of Lipids in Children and Adolescents with Type 1 Diabetes: Towards Individualized Patient Care. Exp Clin Endocrinol Diabetes. 2021 Jul;129(7):510-518.

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Carotid intima media thickness (CIMT) increased in people with type 1 diabetes

Van der Heyden JC, Birnie E, Bovenberg SA, Cabezas MC, van der Meulen N, Mul D, Veeze HJ, Aanstoot HJ.

Do traditional cardiovascular risk factors solely explain intima-media thickening in youth with type 1 diabetes? J Diabetes Complications. 2016 Aug;30(6):1137-43.

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Skin autofluorescence could be early surrogate marker for diabetic complications

van der Heyden JC, Birnie E, Mul D, Bovenberg S, Veeze HJ, Aanstoot HJ.

Increased skin autofluorescence of children and adolescents with type 1 diabetes despite a well-controlled HbA1c: results from an observational cohort study. BMC Endocr Disord. 2016 Sep 9;16(1):49.

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Gada persistence and diabetes classification

Ten Kate Q, Aanstoot HJ, Birnie E, Veeze H, Mul D.

GADA persistence and diabetes classification. Lancet Diabetes Endocrinol. 2016;4:563–564.

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Can subclinical nerve dysfunction be detected early?

Van der Heyden J, van der Meer P, Birnie E, de Coo IF, Castro Cabezas M, Ozcan B, Veeze H, Visser GH, Aanstoot HJ, Blok JH.

Decreased excitability of the distal motor nerve of young patients with type 1 diabetes mellitus. Pediatr Diabetes. 2013;14:519-25.

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